Comparison of the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) and cocaine: asymmetric generalization

详细信息    查看全文

• 作者：Khorana ; Nantaka ; Pullagurla ; Manik R. ; Young ; Richard ; Glennon ; Richard A.
• 关键词：MDMA ; Ecstasy ; Cocaine ; Psychostimulants ; (&minus ; )MDMA ; (+)MDMA ; Drug discrimination
• 刊名：Drug and Alcohol Dependence
• 出版年：2004
• 出版时间：June 11, 2004
• 年：2004
• 卷：74
• 期：3
• 页码：281-287
• 全文大小：116 K

文摘

Evidence suggests that (±)3,4-methylenedioxymethamphetamine (MDMA) and psychostimulants produce similar but non-identical stimulus effects in animals. To examine this hypothesis, groups of rats were trained to discriminate either MDMA (1.5mg/kg) or cocaine (8mg/kg) from saline vehicle using a two-lever operant procedure under a variable interval (VI) 15s schedule of reinforcement. Once the animals were trained, tests of stimulus generalization were conducted with (±)MDMA, cocaine, S(+)MDMA, and R(−)MDMA. As previously demonstrated, both S(+)MDMA and R(−)MDMA (ED₅₀