Stimulus effects of three sulfur-containing psychoactive agents

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• 作者：Khorana ; Nantaka ; Pullagurla ; Manik R. ; Dukat ; Malgorzata ; Young ; Richard ; Glennon ; Richard A.
• 关键词：Hallucinogens ; Stimulants ; Empathogens ; DOM ; Cocaine ; MDMA ; 2C-T-7 ; 4-MTA ; Drug discrimination
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2004
• 出版时间：August, 2004
• 年：2004
• 卷：78
• 期：4
• 页码：821-826
• 全文大小：312 K

文摘

Two agents gaining popularity on the illicit drug market are the phenylalkylamines 4-MTA and 2C-T-7 [or 1-(4-methylthiophenyl)-2-aminopropane and 2-(2,5-dimethoxy-4-n-propylthiophenyl)-1-aminoethane, respectively]. At this time, there exists a paucity of information on the behavioral actions of these sulfur-containing agents. The present investigation examined these agents, and the N-monomethyl analog of 4-MTA (i.e., 4-MTMA), in tests of stimulus generalization (substitution) using a two-lever drug discrimination task with groups of rats trained to discriminate either the hallucinogen DOM [1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane], the stimulant cocaine, or the empathogen MDMA from vehicle. 4-MTA and its N-monomethyl analog 4-MTMA (ED₅₀