Brain GABA levels in patients with bipolar disorder

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• 作者：Rebecca E. Kaufman ; Michael J. Ostacher ; Elizabeth H. Marks ; Naomi M. Simon ; Gary S. Sachs ; J. Eric Jensen ; Perry F. Renshaw ; Mark H. Pollack
• 关键词：Anxiety ; Bipolar disorder ; GABA ; Glutamate ; Magnetic resonance spectroscopy ; Neuroimaging
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2009
• 出版时间：30 April 2009
• 年：2009
• 卷：33
• 期：3
• 页码：427-434
• 全文大小：471 K

文摘

Purpose

A growing body of research supports an important role for GABA in the pathophysiology of bipolar and other mood disorders. The purpose of the current study was to directly examine brain GABA levels in a clinical sample of bipolar patients.

General methods

We used magnetic resonance spectroscopy (MRS) to examine whole brain and regional GABA, glutamate and glutamine in 13 patients with bipolar disorder compared to a matched group of 11 healthy controls.

Findings

There were no significant differences in GABA, glutamate or glutamine between patients and controls.

Conclusions

Further research is needed to better characterize the GABAergic and glutamatergic effects of pharmacotherapy, anxiety comorbidity and clinical state in bipolar disorder.