The Impact of Newer Treatment Modalities on Survival in Patients With Hepatocellular Carcinoma

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• 作者：Naota Taura ; ^{ntaura-gi@umin.ac.jp} ; Keisuke Hamasaki ; Kazuhiko Nakao ; Tatsuki Ichikawa ; Daisuke Nishimura ; Takashi Goto ; Mariko Fukuta ; Hiroshi Kawashimo ; Masumi Fujimoto ; Koichiro Kusumoto ; Yasuhide Motoyoshi ; Hidetaka Shibata ; Katsumi Eguchi
• 关键词：AFP ; ¦Á-fetoprotein ; HCC ; hepatocellular carcinoma ; PEIT ; percutaneous ethanol injection therapy ; TACE ; transarterial chemoembolization
• 刊名：Clinical Gastroenterology and Hepatology
• 出版年：2006
• 出版时间：September 2006
• 年：2006
• 卷：4
• 期：9
• 页码：1177-1183
• 全文大小：310 K

文摘

Background & Aims: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, although the therapeutic approaches for HCC have progressed rapidly, it remains unknown whether the current management of patients with HCC has reduced its mortality. We analyzed changes of survival rate in patients with HCC over a 20-year period. Methods: Between 1982 and 2001, 463 patients were diagnosed with HCC at our hospital. Subjects were enrolled in the current cohort according to the following inclusion criteria: HCC lesion measuring less than 3 cm in diameter, no evidence of extrahepatic metastasis, and no evidence of main portal vein infiltration/thrombosis. A total of 257 patients with HCC were recruited for this study, and categorized into 5-year intervals. Results: The survival rates improved significantly during the study period. When the patients were stratified according to Child¨CPugh score, only patients with Child¡¯s B showed improved survival rates. Furthermore, patients with surgical resection or transarterial chemoembolization during the latter period had a better prognosis than those during the early period. Conclusions: Our findings suggest that the development of therapeutic interventions for HCC have led to improvements in the prognosis for HCC patients.