Enantioselective addition of diethylzinc to aldehydes catalyzed by o-xylylene-type chiral 1,4-amino alcohols with an aminal structure

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• 作者：Masatoshi Asami ; ^{m-asami@ynu.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Ayano Hasome ; Naoyuki Yachi ; Naoya Hosoda ; Yoshitaka Yamaguchi ; Suguru Ito
• 刊名：Tetrahedron: Asymmetry
• 出版年：2016
• 出版时间：1 May 2016
• 年：2016
• 卷：27
• 期：7-8
• 页码：322-329
• 全文大小：987 K

文摘

A series of o-xylylene-type chiral 1,4-amino alcohols with an aminal structure was synthesized starting from (S)-2-(arylaminomethyl)pyrrolidine, o-bromobenzaldehyde, and a diaryl ketone. The enantioselective addition of diethylzinc to aldehydes was examined by using the 1,4-amino alcohols, and the corresponding chiral secondary alcohols were obtained with high enantioselectivities (up to 98% ee).