Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
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- 作者：Mehlika Dilek Altıntopa ; Ö ; zlem Atlıb ; Sinem Ilgınb ; Rasime Demirelc ; Ahmet Ö ; zdemira ; Zafer Asım Kaplancıklıa ; zakaplan@anadolu.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thiosemicarbazone ; Naphthalene ; Fluorine ; Antifungal activity ; Cytotoxicity ; Genotoxicity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：406-414
- 全文大小：644 K
文摘
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New thiosemicarbazone derivatives were tested against pathogenic yeasts and molds.
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The genotoxicity of the most effective anticandidal agents was evaluated.
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Each derivative was evaluated for its cytotoxicity against A549 and NIH/3T3 cells.
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Compounds 1 and 3 were the most effective anticandidal derivatives.
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Compound 2 was the most promising anticancer agent against A549 cell line.