Ferrocenyl naphthalene diimides as tetraplex DNA binders

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• 作者：Shinobu Sato^a ; ^b ; Shigeori Takenaka^a ; ^b ; ^{shige@che.kyutech.ac.jp}
• 关键词：Ferrocenyl naphthalene diimide ; Tetraplex DNA ; Telomere ; Telomerase ; TRAP ; Electrochemistry
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：21-26
• 全文大小：476 K
• 卷排序：167

文摘

Seven synthetic ferrocenylnaphthalene diimide derivatives (FNDs) interact with tetraplex DNA. Two of the FNDs had the highest affinity for tetraplex DNA with 106 M− 1 order of binding. Three of the FNDs inhibit telomerase activity without inhibiting Taq polymerase. A different three FNDs inhibit both telomerase and Taq polymerase. One of the FNDs didn't inhibit either telomerase or Taq polymerase.