Measuring the bioactivity and molecular conformation of typically globular proteins with phenothiazine-derived methylene blue in solid and in solution: A comparative study using photochemistry and computational chemistry
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- 作者：Fei Dinga ; b ; c ; 1 ; Yong Xied ; 1 ; Wei Penga ; e ; weipeng@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yu-Kui Pengf
- 关键词：Ala ; alanine ; ANOVA ; analysis of variance ; ANS ; 8-anilino-1-naphthalenesulfonic acid ; CD ; circular dichroism ; DNA ; deoxyribonucleic acid ; Ile ; isoleucine ; IRF ; instrument response function ; Leu ; leucine ; Lys ; lysine ; Phe ; phenylalanine ; R ; correlation coefficient ; S.D. ; standard deviation ; Ser ; serine ; Tris ; tris(hydroxymethyl)aminomethane ; Trp ; tryptophan ; Tyr ; tyrosine ; UV/vis ; ultraviolet&ndash ; visible spectroscopy ; Val ; valine
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：69-80
- 全文大小：1777 K
文摘
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The bioactivities of biopolymers are related closely to three-dimensional structures.
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10">The molecular conformations of biomacromolecules were perturbed by phenothiazine-derived agent.
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15">Photochemical properties of tryptophan residues would largely be affected by methylene blue.
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Pharmacological activities of phenothiazine-derived drugs should notably be interfered with globular proteins.