Solubility enhancement of 伪-naphthoflavone by synthesized hydroxypropyl cyclic-(1鈫?)-尾-d-glucans (cyclosophoroases)
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- 作者：Jinglan Piao ; Ahri Jang ; Youngjin Choi ; Muhammad Nazir Tahir ; Yunjoo Kim ; Seyeon Park ; Eunae Cho ; Seunho Jung
- 关键词：Cyclosophoraoses ; Hydroxypropyl cyclosophoraoses ; 伪-Naphthoflavone ; Cyclodextrin ; Complexation ; Solubility
- 刊名：Carbohydrate Polymers
- 出版年：30 January, 2014
- 年：2014
- 卷：101
- 期：Complete
- 页码：733-740
- 全文大小：1316 K
文摘
Rhizobium leguminosarum produces unbranched cyclic 尾-1,2-glucans, cyclosophoraoses (Cys). In the present study, Cys were modified with hydroxypropyl groups via a one step chemical derivatization and the complexation ability and solubility enhancement of hydroxypropyl cyclosophoraoses (HP Cys) with 伪-naphthoflavone (伪-NF) were investigated. In the presence of HP Cys, the aqueous solubility of 伪-NF greatly increased up to 257-fold. Complex formation of HP Cys and 伪-NF was confirmed by nuclear magnetic resonance (NMR), Fourier-transform infrared (FT-IR) spectroscopy, and differential scanning calorimetry (DSC). Furthermore, the morphological structure of 伪-NF with HP Cys was examined using scanning electron microscopy (SEM). A hypothetical model was proposed based on molecular dynamics (MD) simulations and a docking study of 伪-NF with HP Cys. Our results suggest that HP Cys form complexes with 伪-NF and can be utilized as a promising solubilizer. This is the first study to identify carbohydrates that can enhance the solubility of 伪-NF.