Catalysis reaction between sodium 1,2-naphthoquinone-4-sulfonate and hydroxyl ion using captopril as catalyzer and determination of captopril

详细信息    查看全文

• 作者：Linxiao Gao ; Lingli Wu ; Quanmin Li
• 关键词：Captopril ; Sodium 1 ; 2-naphthoquinone-4-sulfonate ; Spectrophotometry ; Catalytic reaction
• 刊名：Analytica Chimica Acta
• 出版年：2008
• 出版时间：26 September 2008
• 年：2008
• 卷：626
• 期：2
• 页码：174-179
• 全文大小：576 K

文摘

A novel and simple spectrophotometric method for the determination of Captopril with sodium 1,2-naphthoquinone-4-sulfonate is established in this paper. The detailed reaction mechanism is proposed and discussed. It is based on the fact that captopril can catalyze the reaction between sodium 1,2-naphthoquinone-4-sulfonate and hydroxyl ion to form 2-hydroxy-1,4-naphthoquinone in buffer solution of pH 13.00. Beer's law is obeyed in a range of 0.64–80 μg mL^−1 at the maximal absorption wavelength of 442 nm. The equation of linear regression is A = 0.05815 + 0.00589C (μg mL^−1), with a linear regression correlation coefficient of 0.9981. The detection limit is 0.3 μg mL^−1, R.S.D. is 0.77 % and the recovery rate is in range of 96.0–103.8 % . Furthermore, the method has been validated and successfully applied to the determination of captopril in pharmaceutical samples.