Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli

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• 作者：Sarang Bani ; Anpurna Kaul ; Beenish Khan ; Vijay Kumar Gupta ; Naresh Kumar Satti ; Krishan Avtar Suri ; Ghulam Nabi Qazi
• 关键词：Euphorbia tirucalli ; Immunosuppressive ; Arthritis ; Flowcytometry ; Intracellular ; IL-2 ; IFN-γ
• 刊名：Journal of Ethnopharmacology
• 出版年：2007
• 出版时间：1 March 2007
• 年：2007
• 卷：110
• 期：1
• 页码：92-98
• 全文大小：484 K

文摘

The present study was undertaken to investigate the anti-arthritic activity of a biopolymeric fraction (BET) from plant Euphorbia tirucalli Boiss (Euphorbiaceae). The fraction showed dose dependent anti-arthritic activity and also showed in vivo immunomodulatory capacity being a major component in inhibiting arthritis. It caused suppression of CD4⁺ and CD8⁺ T cells, inhibition of intracellular Interleukin-2 (IL-2) and Interferon-gamma (IFN-γ) by flowcytometry. It inhibited vascular permeability and the migration of leucocytes at the site of the insult. The oral LD₀ in both rats and mice was more than 2000 mg/kg.