In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities
详细信息 查看全文
- 作者：Satoko Tangea ; Nariaki Fujimotob ; Naoto Uramaruc ; Fung Fuh Wongd ; Kazumi Sugiharae ; Shigeru Ohtaa ; Shigeyuki Kitamurac ; kitamura@nichiyaku.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antiandrogenic activity ; Carbaryl ; Estrogenic activity ; Liver microsomes ; Methiocarb ; Methiocarb sulfoxide ; Plasma
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：289-297
- 全文大小：1599 K
文摘
- •
Methiocarb and carbaryl were hydrolyzed by rat plasma and albumin.
- •
The hydrolyzed products showed strong estrogenic and antiandrogenic activities.
- •
Methiocarb and the hydrolyzed product were oxidized to their sulfoxides.
- •
These conversions were mediated by P450 and flavin-containing monooxygenase.
- •
Their sulfoxide products lacked estrogenic and antiandrogenic activities.