Oleacein with a concentration of 100 渭M inhibited NEP activity, elastase, MMP-9 and IL-8 release from neutrophils by 77.7 卤 2.7%, 21.3 卤 7.8%, 22.7 卤 4.2% and 25.2 卤 5.6%, respectively. Oleacein with a concentration of 50 渭M suppressed CD11b/CD18 expression by 63.6 卤 3.1% and to a lesser extent, increased CD62L expression by 27.3 卤 8.3% on the surface of neutrophils, in comparison with stimulated cells.
Oleacein by inhibiting NEP activity, adhesion molecules expression and elastase release might play a role in the protective effects of olive oil against endothelial injuries.