The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents
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- 作者：Lila Missae Oyama ; Claudia Maria Oller do Nascimento ; June Carnier ; Aline de Piano ; Lian Tock ; Priscila de Lima Sanches ; Fabí ; ola Alvise Corrê ; a Gomes ; Sergio Tufik ; Marco Tú ; lio de Mello
- 关键词：Adipokines ; Obesity ; Energy regulation ; Adolescents ; Visceral fat ; Therapy
- 刊名：Neuropeptides
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：44
- 期：6
- 页码：467-474
- 全文大小：488 K
文摘
Obesity is characterized as an inflammatory state associated with a modification in the pattern of adipokine secretion. The present study aimed to assess the role of anorexigenic and orexigenic neuropeptides and peripheral signals in obese adolescents submitted to 1 year of weight loss interdisciplinary therapy and grouped according to quartiles of weight loss. A total of 111 post-puberty adolescents, with a BMI >95th percentile, were included. Glycemia and lipid profiles were analyzed. Insulin resistance was estimated by HOMA-IR. Cytokine concentrations were measured by ELISA. The results are presented according to quartiles of weight loss: 1st (<2.5 kg) = low; 2nd (2.5–8 kg) = low to moderate; 3rd (8–14 kg) = moderate; and 4th (>14 kg) = massive. The most important finding was that the NPY concentration increased significantly only in the first phase of weight loss. Moreover, α-MSH variation was an independent factor in explaining the NPY changes during the intervention, confirming the role of the α-MSH concentration in the peripheral control of energy balance in obese adolescents. Indeed, BMI reduction was correlated with increased α-MSH (p < 0.05). Massive weight loss promoted a significant increase in α-MSH concentration, and hyperleptinemia was reduced after intervention. All together, our findings, which contribute to our understanding of how orexigenic and anorexigenic systems are regulated by weight loss, will provide insight into the pathogenesis and treatment of obesity and other metabolic diseases, especially in obese adolescents.