Antiproliferative effect of Canavalia brasiliensis lectin on B16F10 cells

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• 作者：Flá ; vio de Oliveira Silva^a ; ^{foliveirasilva@gmail.com" class="auth_mail} ; Priscila das Neves Santos^b ; Evellyne de Oliveira Figueirô ; a^c ; Cristiane Moutinho Lagos de Melo^c ; Juliana Kelle de Andrade Lemoine Neves^c ; Francisco Vassiliepe Sousa Arruda^d ; Joã ; o Batista Cajazeiras^d ; Kyria Santiago do Nascimento^d ; Edson Holanda Teixeira^e ; Benildo Sousa Cavada^e ; Ana Lú ; cia Figueiredo Porto^a ; ^{analuporto@yahoo.com.br" class="auth_mail} ; Valé ; ria Rê ; go Alves Pereira^c
• 关键词：Antiproliferative activity ; ConBr ; Canavalia brasiliensis ; Glucose/manose binding lectin ; Murine melanoma
• 刊名：Research in Veterinary Science
• 出版年：April, 2014
• 年：2014
• 卷：96
• 期：2
• 页码：276-282
• 全文大小：674 K

文摘

Lectins are proteins or glycoproteins with the ability to link to carbohydrates at the cell surface in a specific and reversible manner. Studies have showed that lectins are demonstrate immunomodulatory and antitumor agents. This study aims to evaluate the effect of lectin extracted from the seeds of Canavalia brasiliensis (ConBr) on murine melanoma B16F10 cells by analyzing cell viability, apoptosis index, cell migration, production of cytokines and nitric oxide (NO). Results showed that ConBr was able to reduce cell viability and thwart apoptosis, which could be observed by decrease in cell migration. ConBr also induced NO and IL-12 synthesis. Altogether, these data demonstrate the potential of ConBr as a therapeutic agent for melanoma.