Boron nitride nanotubes radiolabeled with ^99mTc: Preparation, physicochemical characterization, biodistribution study, and scintigraphic imaging in Swiss mice

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• 作者：Daniel Crí ; stian Ferreira Soares^a ; ^dcfs@cdtn.br ; Tiago Hilá ; rio Ferreira^a ; Carolina de Aguiar Ferreira^a ; Valbert Nascimento Cardoso^b ; Edé ; sia Martins Barros de Sousa^a
• 关键词：Functionalized boron nitride nanotubes ; Physicochemical characterization ; Biodistribution study and scintigraphic image
• 刊名：International Journal of Pharmaceutics
• 出版年：2012
• 出版时间：28 February 2012
• 年：2012
• 卷：423
• 期：2
• 页码：489-495
• 全文大小：863 K

文摘

In the present study, boron nitride nanotubes (BNNTs) were synthesized from an innovative process and functionalized with a glycol chitosan polymer in CDTN (Centro de Desenvolvimento da Tecnologia Nuclear) laboratories. As a means of studying their in vivo biodistribution behavior, these nanotubes were radiolabeled with ^99mTc and injected in mice. Their size, distribution, and homogeneity were determined by photon correlation spectroscopy (PCS), while their zeta potential was determined by laser Doppler anemometry. The morphology and structural organization were evaluated by scanning electron microscopy (SEM). The functionalization in the nanotubes was evaluated by thermogravimetry analysis (TGA) and Fourier transformer infrared spectroscopy. The results showed that BNNTs were obtained and functionalized successfully, reaching a mean size and dispersity deemed adequate for in vivo studies. The BNNTs were also evaluated by ex vivo biodistribution studies and scintigraphic imaging in healthy mice. The results showed that nanostructures, after 24 h, having accumulated in the liver, spleen and gut, and eliminated via renal excretion. The findings from this study reveal a potential application of functionalized BNNTs as new potential drugs or radioisotope nanocarriers to be applied in therapeutic procedures.