Kit formulation for ^99mTc-labeling of HYNIC-¦ÂAla-Bombesin_(7-14)

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• 作者：Andr¨¦ Lu¨ªs Branco de Barros ; Luciene das Gra?as Mota ; Carolina de Aguiar Ferreira ; Valbert Nascimento Cardoso
• 关键词：Kit formulation ; Freeze-drying/lyophilization ; Radiolabeling ; Bombesin ; Technetium-99m
• 刊名：Applied Radiation and Isotopes
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：70
• 期：10
• 页码：2440-2445
• 全文大小：309 K

文摘

Bombesin (BBN) is a tetradecapeptide that binds specifically to gastrin-releasing peptide receptors. Several forms of cancer, including lung, prostate, breast, and colon express receptors for bombesin-like peptides. Radiolabeled BBN analogs with a high affinity for these receptors might be used for scintigraphic imaging. Kit formulations for labeling these molecules are important for routine preparation. A freeze-dried kit for labeling HYNIC-¦ÂAla-Bombesin_(7-14) with technetium-99m was prepared, and its storage stability was evaluated by in vitro and in vivo assays.