Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts

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• 作者：Jaber Nasiri ; Elaheh Motamedi ; ^{motamedi.elaheh@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mohammad Reza Naghavi ; ^{mnaghavi@ut.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Paclitaxel ; Reduced graphene oxide ; Graphite oxide ; Purification ; Carbon nanotube
• 刊名：Journal of Pharmaceutical Analysis
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：5
• 期：6
• 页码：396-399
• 全文大小：1436 K

文摘

Graphite oxide (GO) and reduced graphene oxide (rGO) nanosheets were synthesized with a low-cost manufacturing method. The morphology and structures of the synthesized samples were studied using X-ray diffraction (XRD), atomic force microscopy (AFM), Fourier-transform infrared (FTIR) and Raman spectroscopy. The efficiencies of GO and rGO as novel candidate adsorbents in the pre-purification of paclitaxel were compared and contrasted with those of commercial graphite (Gt), graphene (G) and multi-wall carbon nanotube (MWCNT). According to UV–vis and HPLC analyses, rGO was evaluated as the best absorbent for the removal of impurities in pre-purification of paclitaxel from plant cell cultures. In contrast, the GO had the poorest proficiency for paclitaxel pre-purification in comparison with the other carbonaceous adsorbents. This is attributed to the existence of many localized defects in the π-structure of GO that is related to weakness of π–π stacking interactions between crude extract impurities and GO.