- 作者：Renato Polimanti ; Ph.D.a ; Sara Piacentini ; Ph.D.a ; Natalia Lazzarin ; M.D. ; Ph.D.b ; Elena Vaquero ; M.D.c ; Maria Antonietta Re ; Ph.D.b ; Dario Manfellotto ; M.D.b ; Maria Fuciarelli ; Ph.D.a ; fuciarelli@uniroma2.it
- 关键词：Pregnancy loss ; phase II enzymes ; genetic predisposition ; GSTA1*-69C/T ; GSTM1 null
- 刊名：Fertility and Sterility
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：98
- 期：2
- 页码：396-400
- 全文大小：131 K
Objective
To investigate the role of glutathione S-transferases (GSTs) in the pathogenesis of recurrent miscarriage (RM).Design
Genetic association study.
Setting
University of Rome, Tor Vergata and San Giovanni Calibita, Fatebenefratelli Hospital.
Patient(s)
One hundred twenty-one women with RM and 113 women without pregnancy complications.
Intervention(s)
Genomic DNA extracted from buccal cells and screening of positive/null genotypes of GSTM1 and GSTT1 genes and single nucleotide polymorphisms of GSTA1, GSTO2, and GSTP1 genes.
Main Outcome Measure(s)
Occurrence of GST polymorphisms.
Result(s)
Women with at least one GSTA1*-69T allele are more frequent in the RM group than in the control group: 67 % vs. 48 % , respectively. Significant outcomes were obtained considering different genetic models: codominant, dominant, and log-additive. In addition, the combined analysis suggests that GSTA1 and GSTM1 variants have a significant interaction in RM risk.
Conclusion(s)
Our study highlighted a significant association between the GSTA1 gene and an increased risk of RM. In particular, the -69T allele in the GSTA1 gene may be considered as a predisposing factor of RM.