Kdr mutations in Triatoma infestans from the Gran Chaco are distributed in two differentiated foci: Implications for pyrethroid resistance management
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- 作者：Ivana Sierraa ; 1 ; sierra.ivana@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Natalia Capriottia ; 1 ; nataliacapriotti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Georgina Fronzab ; georginafronza@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Gastó ; n Mougabure-Cuetob ; gmougabure@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sheila Onsa ; sheilaons@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; sheila.ons@presi.unlp.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：kdr ; knockdown resistance ; PASA ; PCR amplification of specific alleles ; REA ; restriction endonuclease assay ; SCI ; southern cone initiative ; SNP ; single nucleotide polymorphism ; TiNaV ; T. infestans sodium channel ; M ; madrejones ; LE ; la esperanza ; LG ; la geró ; nima ; EJ ; el juramento ; EM ; el malá ; PG ; Pampa Grande ; TN ; Tierras Nuevas ; VC ; Villa El Carmen ; Y ; Yacuiba
- 刊名：Acta Tropica
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：208-213
- 全文大小：951 K
文摘
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We analyzed the spreading of kdr mutations in T. infestans populations from the Gran Chaco.
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L1014F mutation is present in the resistance focus from the Argentinean-Bolivian border.
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L925I mutation is present in the resistance focus from the Argentinean Chaco.
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Mutations in the sodium channel is a major cause of pyrethroid resistance in T. infestans.
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PASA and REA assays are sensitive and efficient tools for resistance monitoring in T. infestans.