High prevalence of multidrug-resistant tuberculosis in Georgia

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• 作者：Nino Mdivani ; Ekaterina Zangaladze ; Natalia Volkova ; Ekaterina Kourbatova ; Thea Jibuti ; Natalia Shubladze ; Tamar Kutateladze ; George Khechinashvili ; Carlos del Rio ; Archil Salakaia ; Henry M. Blumberg
• 关键词：Tuberculosis ; Multidrug-resistance ; Prevalence
• 刊名：International Journal of Infectious Diseases
• 出版年：2008
• 出版时间：November 2008
• 年：2008
• 卷：12
• 期：6
• 页码：635-644
• 全文大小：812 K

文摘

ss=""h3"">Summary

ss=""h4"">Background

Tuberculosis (TB) has emerged as a serious public health problem in the country of Georgia. However, little or no data exist on rates and risk factors for drug-resistant TB, including multidrug-resistant (MDR)-TB, in Georgia.

ss=""h4"">Objective

To assess the prevalence and risk factors for drug-resistant TB.

ss=""h4"">Methods

A cross-sectional prospective survey of patients with suspected pulmonary TB was carried out at four sentinel sites (Tbilisi, Zugdidi, Kutaisi, and Batumi) in Georgia between January 1, 2001 and December 31, 2004.

ss=""h4"">Results

Among 1422 patients with suspected pulmonary TB, 996 (70.0 % ) were culture positive; 931/996 (93.5 % ) had drug susceptibility testing performed. Overall, 64.0 % of patients (48.3 % of new and 85.3 % of retreatment cases) had positive cultures for Mycobacterium tuberculosis resistant to ≥1 first-line antituberculosis drugs. The overall prevalence of MDR-TB was 28.1 % (10.5 % of newly diagnosed patients and 53.1 % of retreatment cases). In multivariate analysis, risk factors for MDR-TB included: being a retreatment case (prevalence ratio (PR) = 5.28, 95 % CI 3.95–7.07), history of injection drug use (PR = 1.59, 95 % CI 1.21–2.09), and female gender (PR = 1.36, 95 % CI 1.12–1.65).

ss=""h4"">Conclusions

MDR-TB has emerged as a serious public health problem in Georgia and will greatly impact TB control strategies.