The utility of QSARs in predicting acute fish toxicity of pesticide metabolites: A retrospective validation approach
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- 作者：Natalie Burdena ; natalie.burden@nc3rs.org.uk" class="auth_mail" title="E-mail the corresponding author ; Samuel K. Maynardb ; Lennart Weltjec ; James R. Wheelerd
- 关键词：Pesticides ; Metabolites ; QSARs ; Fish toxicity ; 3Rs
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：241-246
- 全文大小：482 K
文摘
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QSAR models can be used to predict fish acute toxicity of pesticide metabolites.
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An evidence base supporting this approach to reduce fish numbers used is provided.
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QSAR-predicted and experimental fish LC50 values were compared for 150 metabolites.
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There was a good correlation between the predicted and experimental values.
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This approach has utility in the metabolite assessment scheme recommended by EFSA.