Influence of Previous Inflammatory Bowel Disease on the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: A Matched-Pair Analysis
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- 作者：Florence Rabian1 ; Raphael Porcher2 ; Flore Sicre de Fontbrune1 ; Bruno Lioure3 ; Anne Laplace3 ; Stephanie Nguyen4 ; Reza Tabrizi5 ; Stephane Vigouroux5 ; Cé ; cile Tomowiak6 ; Nathalie Maillard6 ; Felipe Suarez7 ; 8 ; Jeremy Delage9 ; Ré ; gis Peffault de Latour1 ; Gé ; rard Socié ; 1 ; 10 ; 11 ; gerard.socie@aphp.fr" class="auth_mail" title="E-mail the corresponding author ; on behalf of the French Society of Bone Marrow Transplantation ; Cell Therapy
- 关键词：Inflammatory bowel disease ; Hematologic malignancies ; Allogeneic hematopoietic stem cell transplantation ; Acute graft-versus-host disease ; Chronic graft-versus-host disease ; Comorbidity index
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：22
- 期：9
- 页码：1721-1724
- 全文大小：369 K
文摘
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The outcomes of the IBD cohort were not significantly different from those of matched controls with respect to NRM and overall survival at 48 months, as well as cumulative incidences of acute and chronic GVHD.
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NRM at 48 months was 19% for patients with IBD and 11% for controls (HR, 4.93; P = .067).
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Overall survival at 48 months was 59% for patients with IBD and 60% for matched controls (HR, 1.35; P = .56).
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IBD should not be considered a contraindication for transplantation.