Reciprocal interference of maternal and infant immunization in protection against pertussis
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- 作者：Pascal Feunou Feunoua ; b ; c ; d ; e ; Nathalie Mielcareka ; b ; c ; d ; e ; Camille Lochta ; b ; c ; d ; e ; camille.locht@pasteur-lille.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pertussis ; Acellular vaccine ; Whole-cell vaccine ; Maternal immunization ; Antibodies
- 刊名：Vaccine
- 出版年：2016
- 出版时间：17 February 2016
- 年：2016
- 卷：34
- 期：8
- 页码：1062-1069
- 全文大小：902 K
文摘
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Maternal immunization protects infant mice against pertussis, but protection wanes rapidly.
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Maternally-derived protection is lost after infant vaccination with the same, but not with a different vaccine.
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Maternal vaccination interferes with infant vaccination in mice.
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The functionality of maternal antibodies is abolished by infant vaccination with the same vaccine.