A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults
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- 作者：Sté ; phane Pilleta ; b ; É ; ric Aubina ; Sonia Tré ; paniera ; Diane Bussiè ; rea ; Michè ; le Dargisa ; Jean-Franç ; ois Poulinc ; Bader Yassine-Diabc ; Brian J. Wardb ; Nathalie Landrya ; Landryn@medicago.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plant-derived quadrivalent influenza vaccine ; Virus-like particles ; Nicotiana benthamiana ; Safety and immunogenicity ; Cell-mediated immunity ; Cross-reactive response
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：168
- 期：Complete
- 页码：72-87
- 全文大小：2072 K
文摘
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Plant-derived virus-like particle quadrivalent influenza vaccine is safe and well-tolerated
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One dose of vaccine elicits a strong, sustained and cross-reactive immune response
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One dose of vaccine satisfy all CHMP surrogate correlates of protection in adults
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The plant-derived vaccine induces HA-specific and cross-reactive memory CD4 T cells