Forkhead box O member FOXO1 regulates the majority of follicle-stimulating hormone responsive genes in ovarian granulosa cells
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- 作者：Maria K. Herndon mkmeyer@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author ; Nathan C. Law nathan_law@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author ; Elyse M. Donaubauer edonaubauer@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author ; Brandon Kyriss1 ; kyrissbp@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mary Hunzicker-Dunn ; mehd@wsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：FOXO1 ; Granulosa cells ; Follicle-stimulating hormone ; RNA deep sequencing
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：434
- 期：Complete
- 页码：116-126
- 全文大小：1459 K
文摘
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RNA deep sequencing detected 13,461 genes in primary rat ovarian granulosa cells.
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RNA deep sequencing showed that FSH regulates 3772 genes ≥2.0-fold.
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Sixty % of the genes regulated by FSH are activated or repressed by FOXO1.
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Pathway Studio Analysis revealed enrichment of genes repressed by FOXO1 in metabolism, signaling, transport, and development.
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Pathway Studio Analysis revealed enrichment of genes activated by FOXO1 in signaling, cytoskeletal functions, and apoptosis.