Magnetic nanoparticles and nanocomposites for remote controlled therapies

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• 作者：Anastasia K. Hauser ; Robert J. Wydra ; Nathanael A. Stocke ; Kimberly W. Anderson ; J. Zach Hilt ; ^{hilt@engr.uky.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Magnetic nanoparticles ; Remote controlled drug delivery ; Nanocomposites
• 刊名：Journal of Controlled Release
• 出版年：2015
• 出版时间：10 December 2015
• 年：2015
• 卷：219
• 期：Complete
• 页码：76-94
• 全文大小：2497 K

文摘

This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.