Production and evaluation of cytotoxic effects of DT386-BR2 fusion protein as a novel anti-cancer agent
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- 作者：Fatemeh Shafiee ; Mohammad Rabbani ; Ali Jahanian-Najafabadi ; jahanian@pharm.mui.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Buforin ; Immunotoxin ; Diphtheria toxin ; Targeted therapy ; Expression
- 刊名：Journal of Microbiological Methods
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：100-105
- 全文大小：568 K
文摘
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A recombinant fusion protein (DT386-BR2) designed and produced as a new immunotoxin for targeted eradication of cancer cells.
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Replacement of native RBD of DT with a cancer specific CPP led to targeted entrance of DT386
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Results indicated cytotoxicity on cancerous cells but not normal cells
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This fusion protein can be used as a drug candidate for preclinical and clinical studies.