A model of progressive photo-oxidative degeneration and inflammation in the pigmented C57BL/6J mouse retina
详细信息 查看全文
- 作者：Riccardo Natolia ; b ; 1 ; riccardo.natoli@anu.edu.au" class="auth_mail" title="E-mail the corresponding author ; Haihan Jiaoa ; 1 ; Nigel L. Barnettc ; d ; e ; Nilisha Fernandoa ; Krisztina Valtera ; b ; Jan M. Provisa ; b ; Matt Rutara
- 关键词：Retinal degenerations ; Age related macular degeneration ; Light damage ; Inflammation ; Oxidative stress ; Photoreceptor cell death
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：114-127
- 全文大小：5399 K
文摘
- •
Novel light damage model using LED technology on pigmented C57BL mice.
- •
Chronic retinal degeneration causing recruitment of macrophages.
- •
Photoreceptor cell death caused altered inflammatory and oxidative damage markers.
- •
Decrease in retinal functional changes in new light damage model.
- •
New model enables the discovery of mechanisms that underpin retinal disease.