The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency
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- 作者：Adela Guará ; s1 ; Ester Perales-Clemente1 ; Enrique Calvo2 ; Rebeca Ací ; n-Pé ; rez1 ; Marta Loureiro-Lopez2 ; Claire Pujol3 ; 4 ; Isabel Martí ; nez-Carrascoso1 ; Estefaní ; a Nuñ ; ez2 ; Fernando Garcí ; a-Marqué ; s2 ; Marí ; a Angeles Rodrí ; guez-Herná ; ndez5 ; 6 ; Ana Corté ; s5 ; 6 ; Francisca Diaz7 ; Acisclo Pé ; rez-Martos9 ; Carlos T. Moraes7 ; 8 ; Patricio Ferná ; ndez-Silva9 ; Aleksandra Trifunovic3 ; 4 ; Plá ; cido Navas5 ; 6 ; Jesú ; s Vazquez2 ; Jose A. Enrí ; quez1 ; 9 ; jaenriquez@cnic.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：15
- 期：1
- 页码：197-209
- 全文大小：3848 K
文摘
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High CoQH2/CoQ ratio induces reverse electron transport under physiological conditions
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RET-generated ROS induces partial complex I degradation
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Increase in the CIII fraction detached of CI optimizes mETC to consume fatty acids
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The CoQH2/CoQ ratio serves as a sensor of respiratory chain efficiency