The role of genomic islands in Escherichia coli K1 interactions with intestinal and kidney epithelial cells
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- 作者：Farzana Abubakar Yousufa ; Sahar Rafiqa ; Ruqaiyyah Siddiquib ; Naveed Ahmed Khanb ; naveed5438@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bacteria ; Pathogenicity ; Invasion ; Survival ; Association ; Epithelial cells
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：145-151
- 全文大小：859 K
文摘
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Genomic islands 16, 18, 21, 22 are important for interactions with intestinal & kidney epithelial cells.
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Notably, plasmid-cured Escherichiacoli K1 showed reduced association, invasion, and intracellular survival of Caco-2 and MA104.
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Genomic islands 4, 14, 15, 16, 21 showed reduced viability in response to normal human serum.
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These findings will help focus our efforts in the discovery of novel virulence factors of therapeutic value.