The effect of peptidic and non-peptidic proteasome inhibitors on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype
详细信息 查看全文
- 作者：Ruqaiyyah Siddiquia ; Sahreena Saleemb ; Naveed Ahmed Khana ; naveed5438@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protozoa ; Acanthamoeba ; Encystation ; Bortezomib ; MG132 ; Lactacystin
- 刊名：Experimental Parasitology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：168
- 期：Complete
- 页码：16-24
- 全文大小：1038 K
文摘
- •
Peptidic and non-peptidic proteasome inhibitors were tested on Acanthamoeba.
- •
Inhibition of proteasome abolished extracellular proteolytic activities.
- •
Proteasome inhibition affected parasite growth but not viability.
- •
Notably, proteasome inhibitors blocked parasite encystation as well as excystation.