Repeated ECS induces GluR1 mRNA but not NMDAR1A-G mRNA in the rat hippocampus
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- 作者：Naylor ; Peter ; Stewart ; Caroline A. ; Wright ; Simon R. ; Pearson ; R. Carl A. ; Reid ; Ian C.
- 关键词：In situ hybridization ; AMPA receptor ; NMDA receptor ; Electroconvulsive stimulation ; Long-term potentiation ; Memory
- 刊名：Molecular Brain Research
- 出版年：1996
- 出版时间：January, 1996
- 年：1996
- 卷：35
- 期：1-2
- 页码：349-353
- 全文大小：389 K
文摘
The neural basis underlying the cognitive side effects of ECT is unknown. Recent studies suggest that the memory dysfunction may be caused by alterations in hippocampal synaptic efficacy [20]. In situ hybridisation was used to examine the possible receptor mechanisms responsible for this effect. Repeated ECS markedly increased mRNA expression for the GluR1 subunit of the AMPA receptor, but not the NMDAR1A-G subtypes of the NMDA receptor, relative to control treatments. This effect was present 24 h after the last seizure and may be responsible for the expression of the ECS-induced increase in synaptic efficacy.