Diffusion Tensor Imaging of Sports-Related Concussion in Adolescents

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• 作者：Naznin Virji-Babul ; PhD^a ; ^b ; ^{nvb31@mail.ubc.ca} ; Michael R. Borich ; PhD^a ; Nadia Makan ; BSc^a ; Tiffany Moore ; BA^a ; Kira Frew ; BHK^a ; Carolyn A. Emery ; PhD^c ; Lara A. Boyd ; PhD^a
• 刊名：Pediatric Neurology
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：48
• 期：1
• 页码：24-29
• 全文大小：448 K

文摘

Concussion is among the least understood neurologic injuries. The impact of concussion on the adolescent brain remains largely unknown. This study sought to establish short-term changes in white-matter integrity after sports-related concussion in adolescents, and examine the association between changes in white-matter integrity and a clinical measure of concussion. Twelve adolescents, aged 14-17 years with a sports-related concussion within 2 months, and 10 age-matched adolescents with no history of concussion were evaluated with the Sports Concussion Assessment Tool 2 and diffusion tensor imaging. Two measures compared the two groups: fractional anisotropy and mean diffusivity. Whole-brain fractional anisotropy values significantly increased (F(1,40)?= 6.29, P?= 0.010), and mean diffusivity values decreased (F(1,40)?= 4.75, P?= 0.036), in concussed athletes compared with control participants. Total scores on the Sports Concussion Assessment Tool 2 were associated with whole-brain fractional anisotropy. Mean diffusivity values with lower scores were associated with higher fractional anisotropy (R²?= 0.25, P?= 0.017) and lower mean diffusivity (R²?= 0.20, P?= 0.038). We provide evidence of structural changes in the integrity of white matter in adolescent athletes after sports-related concussion.