Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos
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- 作者：Olga Celaa ; 1 ; Rosella Scrimaa ; 1 ; Valerio Pazienzab ; Giuseppe Merlac ; Giorgia Benegiamob ; 2 ; Bartolomeo Augelloc ; Sabino Fugettoa ; Marta Mengaa ; Rosa Rubinod ; Luise Fuhre ; f ; Angela Reló ; gioe ; f ; Claudia Piccolia ; Gianluigi Mazzoccolid ; g.mazzoccoli@operapadrepio.it" class="auth_mail" title="E-mail the corresponding author ; Nazzareno Capitanioa ; nazzareno.capitanio@unifg.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitochondria ; Clock-genes ; Oxidative phosphorylation ; Complex I ; NAD ; Sirtuins
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1863
- 期：4
- 页码：596-606
- 全文大小：3206 K
文摘
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Synchronized cultured cells unveil endogenous oscillating mitochondrial respiration linked to expression of the circadian core-clock genes.
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Oscillating respiration in independent on the protocol of synchronization, cell type and metabolic substrates.
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Oscillating respiration correlates with rhythmic activity of mitochondrial Complex I.
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Oscillating respiration is linked to expression of NAMPT and Sirt1/3 and NAD synthesis.
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The reversible acetylation state of Complex I correlates with its rhythmic activity.