MicroRNA-712 restrains macrophage pro-inflammatory responses by targeting LRRK2 leading to restoration of insulin stimulated glucose uptake by myoblasts
MicroRNA-712 levels are significantly down-regulated in inflamed macrophages. Forced expression of miR-712 reduced pro-inflammatory responses of macrophages. miR-712 targets 3′ UTR of LRRK2. Over-expression of miR-712 in macrophages blocked their paracrine effects on insulin sensitivity. Restoration of miR-712 expression may ameliorate inflammation induced insulin resistance.