HIV-1 Reservoirs During Suppressive Therapy

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• 作者：Kirston Barton¹ ; Anni Winckelmann¹ ; ² ; Sarah Palmer¹ ; ^{sarah.palmer@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：HIV-1 ; latent HIV-1 ; HIV-1 reservoirs ; long-term ART ; memory CD4+ T cells ; persistent HIV-1
• 刊名：Trends in Microbiology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：24
• 期：5
• 页码：345-355
• 全文大小：1838 K

文摘

The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced morbidity and mortality associated with HIV-1. Initially there was hope that ART would be curative, but it quickly became clear that even though ART was able to restore CD4⁺ T cell counts and suppress viral loads below levels of detection, discontinuation of treatment resulted in a rapid rebound of infection. This is due to persistence of a small reservoir of latently infected cells with a long half-life, which necessitates life-long ART. Over the past few years, significant progress has been made in defining and characterizing the latent reservoir of HIV-1, and here we review how understanding the latent reservoir during suppressive therapy will lead to significant advances in curative approaches for HIV-1.