Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase
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- 作者：Alper Cobana ; acoban@umc.edu" class="auth_mail" title="E-mail the corresponding author ; Russell L. Carra ; russell.carr@cvm.msstate.edu" class="auth_mail" title="E-mail the corresponding author ; Howard W. Chambersb ; hwc2@msstate.edu" class="auth_mail" title="E-mail the corresponding author ; Kenneth O. Willefordb ; kwilleford@bch.msstate.edu" class="auth_mail" title="E-mail the corresponding author ; Janice E. Chambersa ; chambers@cvm.msstate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AChE ; acetylcholinesterase ; ATCh ; acetylthiocholine iodide ; DFP ; diisopropyl fluorophosphate ; DTNB ; 5 ; 5&prime ; -dithio-bisnitrobenzoic acid ; MOPS ; 3-[N-morpholino] propane sulfonic acid ; NCMP ; nitrophenyl cyclohexyl methylphosphonate ; NEMP ; nitrophenyl ethyl methylphosphonate ; NIMP ; nitrophenyl isopropyl methylphosphonate ; PIMP ; phthalimidyl isopropyl methylphosphonate ; TEMP ; 3 ; 5 ; 6-trichloro-2-pyridinyl ethyl methylphosphonate ; TIMP ; 3 ; 5 ; 6-trichloro-2-pyridinyl isopropyl methylphosphonate ; TRIS
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：25 April 2016
- 年：2016
- 卷：248
- 期：Complete
- 页码：39-45
- 全文大小：979 K
文摘
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Inhibition kinetic assays were conducted with several highly relevant surrogates for sarin, VX and cyclosarin and insecticidal organophosphates in rat brain, mouse brain and purified human erythrocyte acetylcholinesterase.
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With the exception of chlorpyrifos-oxon, the nerve agent surrogates were more potent inhibitors than the other organophosphates.
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The potencies of the nerve agent surrogates were proportional to the toxicities of the nerve agents, cyclosarin > VX > sarin.