MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators

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• 作者：Akemi Takata^a ; Motoyuki Otsuka ; ^a ; ^{otsukamo-tky@umin.ac.jp" rel="nofollow} ; Kentaro Kojima^a ; Takeshi Yoshikawa^a ; Takahiro Kishikawa^a ; Haruhiko Yoshida^a ; Kazuhiko Koike^a
• 关键词：NF-κ ; B ; MicroRNA ; NCOA1 ; NRIP1
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2011
• 出版时间：12 August 2011
• 年：2011
• 卷：411
• 期：4
• 页码：826-831
• 全文大小：739 K

文摘

Nuclear factor κB (NF-κB) is a transcription factor that regulates a set of genes that are critical to many biological phenomena, including liver tumorigenesis. To identify microRNAs (miRNAs) that regulate NF-κB activity in the liver, we screened 60 miRNAs expressed in hepatocytes for their ability to modulate NF-κB activity. We found that miRNA-22 and miRNA-140-3p significantly suppressed NF-κB activity by regulating the expression of nuclear receptor coactivator 1 (NCOA1) and nuclear receptor-interacting protein 1 (NRIP1), both of which are NF-κB coactivators. Our results provide new information about the roles of miRNAs in the regulation of NF-κB activity.