Effect of substituent of terpyridines on the in vitro antioxidant, antitubercular, biocidal and fluorescence studies of copper(II) complexes with clioquinol

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• 作者：G.J. Kharadi
• 关键词：CQ ; clioquinol ; L ; L1 ; L2 ; L3 ; L1 ; 4&prime ; -(4-bromophenyl)-2 ; 2&prime ; 6&prime ; 2&prime ; &prime ; -terpyridine ; L2 ; 4&prime ; -(4-fluorophenyl)-2 ; 2&prime ; 6&prime ; 2&prime ; &prime ; &ndash ; terpyridine ; L3 ; 4&prime ; -(4-methoxyphenyl)-2 ; 2&prime ; 6&prime ; 2&prime ; &prime ; -terpyridine ; C1 ; [Cu(L1)(CQ)Cl]&sdot ; 3H2O ; C2 ; [Cu(L2)(CQ)Cl]&sdot ; H2O ; C3 ; [Cu(L3)(CQ)Cl]&sdot ; 2H2O ; B.M. ; Bohr magneton ; TGA ; thermogravimetric analysis ; LB ; Luria Broth
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：3 January, 2014
• 年：2014
• 卷：117
• 期：Complete
• 页码：662-668
• 全文大小：1003 K

文摘

An octahedral complexes of copper with clioquinol(CQ) and substituted terpyridine have been synthesized. The Cu(II) complexes have been characterized by elemental analyses, thermogravimetric analyses, magnetic moment measurements, FT-IR, electronic, ¹H NMR and FAB mass spectra. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. Ferric-reducing anti-oxidant power of all complexes were measured. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. The antimicrobial efficiency of the complexes were tested on five different microorganisms and showed good biological activity.