Ribonuclease-Mediated Control of Body Fat
详细信息 查看全文
- 作者：Cornelia Habacher1 ; 2 ; Yanwu Guo1 ; Richard Venz1 ; 2 ; Pooja Kumari1 ; Anca Neagu1 ; Dimos Gaidatzis1 ; 4 ; Eva B. Harvald3 ; Nils J. Fæ ; rgeman3 ; Heinz Gut1 ; Rafal Ciosk1 ; 5 ; rafal.ciosk@fmi.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：MCPIP1 ; Zc3h12a ; Regnase-1 ; REGE-1 ; ETS-4 ; lipid metabolism ; obesity ; innate immunity ; RNA degradation ; PIN domain
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：7 November 2016
- 年：2016
- 卷：39
- 期：3
- 页码：359-369
- 全文大小：3119 K
文摘
- m" id="list_ulist0010">
- •
REGE-1, related to the RNase MCPIP1/Zc3h12a/Regnase-1, controls fat in
- •
REGE-1 degrades mRNA encoding the transcription factor ETS-4
- •
ETS-4 induces expression of fat metabolic and defense genes
- •
REGE-1 and ETS-4 form a dynamic, auto-regulatory module controlling body fat