- 作者：Ivana Hollan ; Manuela Nebuloni ; Barbara Bottazzi ; Knut Mikkelsen ; ?ystein T. F?rre ; Sven Martin Almdahl ; Alberto Mantovani ; Morten Wang Fagerl ; P?l Aukrust ; Pier Luigi Meroni ; on behalf of the Feiring Heart Biopsy Study Group
- 关键词：Inflammation ; Pentraxin 3 ; Atherosclerosis ; Rheumatoid arthritis
- 刊名：Cardiovascular Pathology
- 出版年：2013
- 出版时间：September-October, 2013
- 年：2013
- 卷：22
- 期：5
- 页码：324-331
- 全文大小：2828 K
Background
The aims were to evaluate the presence and extent of pentraxin 3 depositions in specimens from the outer layers of the aorta and from the internal thoracic artery of patients with coronary artery disease with and without rheumatoid arthritis and to search for relationships between pentraxin 3 and vascular inflammation.Methods
Using histochemistry and immunohistochemistry, we examined biopsies from the aortic adventitia and from the internal thoracic artery (both with adjacent perivascular tissue), removed during coronary artery bypass grafting in 19 rheumatoid arthritis and 20 non-rheumatoid-arthritis patients, for presence/extent of pentraxin 3 depositions, inflammatory cell infiltrates, and fibrosis.
Results
In the aorta, pentraxin 3 deposition occurred in all specimens, mostly at sites with inflammatory cell infiltrates or fibrosis, and their extent was related to the extent of inflammatory cell infiltrates (rho=0.43, 95 % confidence interval: 0.13-0.66, P=.007). The extent of pentraxin 3 and inflammatory cell infiltrates in the aorta was similar in rheumatoid arthritis and non-rheumatoid-arthritis patients, but rheumatoid arthritis patients had more fibrosis and a lower proportion of T-cells in inflammatory cell infiltrates. In the internal thoracic artery, pentraxin 3 occurred only in 36 % patients, and inflammatory cell infiltrates and fibrosis occurred in none.
Conclusions
Pentraxin 3 depositions in the outer aortic layers are common and are related to the local inflammation. On the other hand, they occur less frequently in the internal thoracic artery, i.e., a vessel highly resistant to atherosclerosis. Rheumatoid arthritis patients had more pronounced fibrosis in the aortic specimens and a different leukocytic response than non-rheumatoid-arthritis patients. In theory, pentraxin 3 might modulate the inflammatory process involved in the pathogenesis of cardiovascular disease and represent a target for new therapies.