CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis

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• 作者：Yvonne Baumer^a ; ¹ ; Sara McCurdy^a ; ¹ ; Martin Alcala^b ; Nehal Mehta^c ; Bog-Hieu Lee^d ; ^{lbheelb@cau.ac.kr} ; Mark H. Ginsberg^e ; William A. Boisvert^a ; ^f ; ^{wab@hawaii.edu}
• 关键词：Vascular smooth muscle cell ; CD98 ; Cell proliferation ; Apoptosis ; Atherosclerosis
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：105-114
• 全文大小：5294 K
• 卷排序：256

文摘

CD98 deficiency severely limits vascular smooth muscle cell proliferation. Atherosclerotic mice lacking CD98 in their smooth muscle cells have reduced vascular smooth muscle cells in their plaque. Plaques from CD98-deficient mice have significantly larger necrotic core. Breaks in elastin layer of atherosclerotic plaques are reduced in CD98 deficiency. CD98 may play an important role in plaque stability.