Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment

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• 作者：K.-S.N. Atretkhany^a ; ^b ; M.S. Drutskaya^a ; ^b ; S.A. Nedospasov^a ; ^b ; ^c ; S.I. Grivennikov^a ; ^d ; ^{sergey.grivennikov@fccc.edu} ; D.V. Kuprash^a ; ^b ; ^{kuprash@eimb.ru}
• 关键词：Inflammation ; Tumor ; Cancer ; Chemokines ; Cytokines ; Exosomes
• 刊名：Pharmacology & Therapeutics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：168
• 期：Complete
• 页码：98-112
• 全文大小：1366 K
• 卷排序：168

文摘

Relationship between inflammation and cancer is now well-established and represents a paradigm that our immune response does not necessarily serves solely to protect us from infections and cancer. Many specific mechanisms that link chronic inflammation to cancer promotion and metastasis have been uncovered in the recent years. Here we are focusing on the effects that tumors may exert on inflammatory cascades, tuning the immune system ability to cause tumor promotion or regression. In particular, we discuss the contributions of chemokines, cytokines and exosomes to the processes such as induction of inflammation and tumorigenesis. Overall, tumor-elicited inflammation is a key driver of tumor progression and an essential component of tumor microenvironment.