PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain
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- 作者：Shweta Hegdea ; Hao Jib ; David Oliverb ; Neema S. Patela ; Nicolas Pouporea ; Michael Shtutmanb ; Michy P. Kellya ;
- 关键词：ANOVA ; analysis of variance ; CREB ; cAMP-response element binding protein ; GH ; group housed ; HT ; heterozygous ; KO ; knockout ; PDE11A ; Phosphodiesterase 11A ; Q-PCR ; quantitative PCR ; SI ; socially isolated ; VHIPP ; ventral hippocampal formation ; WT ; wild-type
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：29 October 2016
- 年：2016
- 卷：335
- 期：Complete
- 页码：151-169
- 全文大小：3080 K
文摘
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Adult—not adolescent—PDE11A mutant mice exhibit sex-dependent social deficits in select social contexts but not others.
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C57BL/6J mice prefer to interact with PDE11A WT mice while PDE11A KO mice prefer to interact with other PDE11A KO mice.
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Social isolation decreases PDE11A4 protein and impairs subsequent social behaviors in a PDE11A genotype-dependent manner.
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Deletion of PDE11A4 alters gene expression in the oxytocin signaling pathway, a key regulator of social behaviors.