Advances in Chromobacterium violaceum and properties of violacein-Its main secondary metabolite: A review

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• 作者：Nelson Dur&aacute ; n^a ; ^b ; ^c ; ^{duran@iqm.unicamp.br" class="auth_mail" title="E-mail the corresponding author} ; Giselle Z. Justo^d ; Marcela Dur&aacute ; n^b ; ^e ; Marcelo Brocchi^f ; Livia Cordi^b ; ^f ; Ljubica Tasic^a ; ^b ; Guillermo R. Castro^g ; Gerson Nakazato^h
• 关键词：Violacein ; Chromobacterium violaceum ; Antrimicrobial ; Anticancer ; Antiparasitic ; Industrial applications
• 刊名：Biotechnology Advances
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：34
• 期：5
• 页码：1030-1045
• 全文大小：1234 K

文摘

Chromobacterium violaceum is important in the production of violacein, like other bacteria, such as Alteromonas, Janthinobacterium, Pseudoalteromonas, Duganella, Collimonas and Escherichia. Violacein is a versatile pigment, where it exhibits several biological activities, and every year, it shows increasing commercially interesting uses, especially for industrial applications in cosmetics, medicines and fabrics. This review on violacein focuses mainly on the last five years of research regarding this target compound and describes production and importance of quorum sensing in C. violaceum, mechanistic aspects of its biosynthesis, monitoring processes, genetic perspectives, pathogenic effects, antiparasitic and antimicrobial activities, immunomodulatory potential and uses, antitumor potential and industrial applications.