Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer
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- 作者：Gregor Tevza ; 1 ; Sean McGrathb ; Ryan Demeterb ; Vincent Magrinib ; Varinder Jeeta ; Anja Rockstroha ; Stephen McPhersona ; John Laia ; Nenad Bartonicekd ; Jiyuan Ana ; Jyotsna Batraa ; Marcel E. Dingerd ; e ; Melanie L. Lehmana ; c ; Elizabeth D. Williamsa ; Colleen C. Nelsona ; c ; colleen.nelson@qut.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prostate cancer ; RLN1 ; RLN2 ; Fusion ; SMRT sequencing ; RNA-Seq
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：420
- 期：Complete
- 页码：159-168
- 全文大小：1978 K
文摘
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A novel RLN1-RLN2 fusion was observed in LNCaP cells and normal and prostate cancer tissues.
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The fusion putatively encodes a RLN2 isoform with a deleted secretory signal peptide.
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RLN1 is underrepresented in PCa cell lines.
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Androgens inversely regulate RLN1 and the RLN1-RLN2 fusion transcript.