Resistant nematodes in cattle: Pharmaco-therapeutic assessment of the ivermectin- ricobendazole combination

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• 作者：Candela Canton^a ; ^{ccanton@vet.unicen.edu.ar} ; Laura Ceballos^a ; Cé ; sar Fiel^b ; Laura Moreno^a ; Pablo Domingo Yagü ; ez^c ; Gisele Bernat^b ; Carlos Lanusse^a ; Luis Alvarez^a
• 关键词：Ivermectin ; Ricobendazole ; Nematodicidal combination ; Pharmacokinetic interaction ; Anthelmintic resistance ; Pharmaco-parasitological assessment
• 刊名：Veterinary Parasitology
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：234
• 期：Complete
• 页码：40-48
• 全文大小：771 K
• 卷排序：234

文摘

No pharmacokinetic interactions were observed between ivermectin and ricobendazole. Individual and combined use of both drugs did not alter any of the PK parameters. The combination achieved an additive effect against IVM-resistant nematodes. The combination would lead to lower contamination of the pasture than the RBZ alone.