Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

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• 作者：Lilach Soreq¹ ; ² ; UK Brain Expression Consortium
• 关键词：aging ; gene expression ; machine learning ; immunohistochemistry ; brain ; neurons ; olgiodendrocytes ; microglia ; exon microarrays ; RNA-seq
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：557-570
• 全文大小：7093 K
• 卷排序：18

文摘

Understanding the role of cell-type-specific changes in human brain aging Glial-specific genes shift their regional expression patterns during aging Oligodendrocytes and neuronal subpopulations are decreased in the aging neocortex Microglia-specific genes globally increase their expression during aging