Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c

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• 作者：Kacey E. Rajkovich¹ ; Kristofer W. Loerwald¹ ; Carly F. Hale¹ ; Carolyn T. Hess¹ ; Jay R. Gibson¹ ; ^{jay.gibson@utsouthwestern.edu} ; Kimberly M. Huber¹ ; ² ; ^{kimberly.huber@utsouthwestern.edu}
• 关键词：barrel cortex ; transcription factor ; local ; long-range ; connectivity ; input pathway ; evoked ; spontaneous ; synaptic transmission
• 刊名：Neuron
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：93
• 期：1
• 页码：48-56
• 全文大小：3752 K
• 卷排序：93

文摘

Postsynaptic MEF2C differentially regulates distinct inputs onto L2/3 neurons MEF2C increases the number of local excitatory inputs onto L2/3 neurons MEF2C suppresses the strength of long-range excitatory cortical L2/3 inputs Experience-dependent development of excitatory L2/3 inputs requires MEF2C